Standardized EEG for multi-site biomarker-informed trials: Implementation in the Canadian Biomarker Integration Network in Depression
Benjamin Schwartzmann, Prabhjot Dhami, Raaj Chatterjee, Pierre Blier, Jane A Foster, Stefanie Hassel, Keith Ho, Raymond W Lam, Roumen Milev, Daniel J Müller, Sagar V Parikh, Franca Placenza, Lena C Quilty, Joshua Rosenblat, Claudio N Soares, Valerie H Taylor, Gustavo Turecki, Susan Rotzinger, Sidney H Kennedy, Rudolf Uher, Benicio N Frey, Faranak Farzan
Objectives
To standardize EEG practices in research and facilitate the transition to multi-site biomarker-informed clinical trials, with the aim of enhancing the treatment of depression and other neuropsychiatric disorders.
Methods
This study details the approaches employed by the Canadian Biomarker Integration Network in Depression (CAN-BIND), a collaborative, multi-site network supported by the Ontario Brain Institute and Brain Canada, focused on enhancing depression care. To achieve our objective, we implemented strategies to reduce variability across CAN-BIND sites participating in EEG data collection.
Results
We implemented standardization solutions in three key areas: infrastructure, procedures, and toolboxes. As part of this initiative, we developed two novel toolboxes designed to automatically clean EEG data and ensure that high-quality standards are met prior to biomarker extraction, enhancing the homogeneity of collected EEG data.
Conclusions
Achieving standardization of EEG procedures in multi-site studies is essential for the successful implementation of biomarker-informed clinical trials.
Significance
Our study offers comprehensive solutions for EEG practices across multiple sites, providing valuable insights and inspiration for establishing standardization approaches in collaborative neuroimaging efforts beyond depression research.