Sept 27, 2024
Researchers at the eBrain Lab have found that the brain's rapidly fluctuating activity at a global level significantly shapes its response to neurostimulation.
Researchers at the eBrain Lab have found that the brain's rapidly fluctuating activity at a global level significantly shapes its response to neurostimulation. Published in the Journal of Neuroscience, their study used transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) to discover that stimulating the brain during a specific global state —known as Microstate C—elicited a significantly larger response to neurostimulation compared to other brain states.
The findings suggest that the neurophysiological factors which influence how the brain responds to neurostimulation extend beyond just the local area which is directly targeted. By demonstrating that large-scale brain state patterns impact stimulation outcomes, the study underscores the importance of incorporating dynamic global states into brain stimulation protocols. This brings us closer to closed-loop neurostimulation and could optimize therapies like repetitive TMS for depression while advancing brain-computer interface technologies.
To learn more about these exciting findings, we encourage you to read the full article here.