Major Depressive Disorder (MDD) affects approximately one in ten adolescents and youth, with these rates having increased over the past decade. Unfortunately, up to 50 % of youth will not respond to initial treatments, underscoring the need to gain a better understanding of both the biology of MDD in youth, and how to effectively treat it. A major research arm of eBrain Lab is devoted to using various neurotechnological tools, including electroencephalography (EEG) and transcranial magnetic stimulation (TMS), to study both the pathophysiology of MDD in youth and how various kinds of antidepressant treatments (such as repetitive TMS) work to treat MDD in this clinical population.
Subsequent to global initiatives in mapping the human brain and investigations of neurobiological markers for brain disorders, the number of multi-site studies involving the collection and sharing of large volumes of brain data, including electroencephalography (EEG), has been increasing. Among the complexities of conducting multi-site studies and increasing the shelf life of biological data beyond the original study are timely standardization and documentation of relevant study parameters. We present the insights gained and guidelines established within the EEG working group of the Canadian Biomarker Integration Network in Depression (CAN-BIND).
CAN-BIND is a multi-site, multi-investigator, and multi-project network supported by the Ontario Brain Institute with access to Brain-CODE, an informatics platform that hosts a multitude of biological data across a growing list of brain pathologies